BMRB Entry 5837
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR5837
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Title: Structure of a peptide derived from the voltage gated Na+ channel and its selective interaction with local anesthetic as determined by NMR spectroscopy PubMed: 16687202
Deposition date: 2003-06-18 Original release date: 2008-06-27
Authors: Fraceto, Leonardo; Nakaie, Clovis; Spisni, Alberto; de Paula, Eneida; Pertinhez, Thelma
Citation: Fraceto, Leonardo; Oyama, Sergio; Nakaie, Clovis; Spisni, Alberto; de Paula, Eneida; Pertinhez, Thelma. "Interaction of local anesthetics with a peptide encompassing the IV/S4-S5 linker of the Na+ channel." Biophys. Chem. 123, 29-39 (2006).
Assembly members:
Sodium Channel, polymer, 21 residues, Formula weight is not available
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: chemical synthesis
Entity Sequences (FASTA):
Sodium Channel: KGIRTLLFALMMSLPALFNI
G
- assigned_chemical_shifts
| Data type | Count |
| 1H chemical shifts | 163 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | Sodium channel subunit 4 | 1 |
Entities:
Entity 1, Sodium channel subunit 4 21 residues - Formula weight is not available
| 1 | LYS | GLY | ILE | ARG | THR | LEU | LEU | PHE | ALA | LEU | ||||
| 2 | MET | MET | SER | LEU | PRO | ALA | LEU | PHE | ASN | ILE | ||||
| 3 | GLY |
Samples:
sample_1: Sodium Channel 1.0 mM; trifluethanol 30%
condition_1: pH: 4.1; temperature: 293 K
Experiments:
| Name | Sample | Sample state | Sample conditions |
|---|---|---|---|
| COSY | not available | not available | not available |
| TOCSY | not available | not available | not available |
| NOESY | not available | not available | not available |
| ROESY | not available | not available | not available |
| 15N-HSQC | not available | not available | not available |
| DOSY | not available | not available | not available |
Software:
Felix v2000 -
NMR spectrometers:
- Varian INOVA 600 MHz
- Varian INOVA 500 MHz
Related Database Links:
| DBJ | BAA07195 BAA78033 BAA90445 BAA90446 BAA90447 |
| EMBL | CAA25587 CAA27286 CAA27287 CAA46439 CAA58042 |
| GB | AAA18895 AAA41682 AAA42114 AAA58644 AAA60554 |
| PRF | 1012288A 1204264A 1204264B 2117364A 2203417A |
| REF | NP_000325 NP_000326 NP_001002994 NP_001003203 NP_001034914 |
| SP | O08562 O46669 O88420 P02719 P04774 |
| TPG | DAA17127 DAA17236 DAA30006 DAA32687 DAA32692 |
| AlphaFold | O08562 O46669 O88420 P02719 P04774 |