BMRB

Biological Magnetic Resonance Data Bank


A Repository for Data from NMR Spectroscopy on Proteins, Peptides, Nucleic Acids, and other Biomolecules
Member of WWPDB

BMRB Entry 6016

Title: Backbone resonance assignments of the 45.3 kDa catalytic domain of human BACE1

Deposition date: 2003-11-19 Original release date: 2004-07-08

Authors: Liu, Dingjiang; Wang, Yu-sen; Gesell, Jennifer; Wilson, Eileen; Beyer, Brian; Wyss, Daniel

Citation: Liu, Dingjiang; Wang, Yu-sen; Gesell, Jennifer; Wilson, Eileen; Beyer, Brian; Wyss, Daniel. "Letter to the Editor: Backbone resonance assignments of the 45.3 kDa catalytic domain of human BACE1"  J. Biomol. NMR 29, 425-426 (2004).

Assembly members:
beta-site APP Cleaving Enzyme 1, polymer, 407 residues, Formula weight is not available

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:   Production method: recombinant technology

Entity Sequences (FASTA):
beta-site APP Cleaving Enzyme 1: DEEPEEPGRRGSFVEMVDNL RGKSGQGYYVEMTVGSPPQT LNILVDTGSSNFAVGAAPHP FLHRYYQRQLSSTYRDLRKG VYVPYTQGKWEGELGTDLVS IPHGPNVTVRANIAAITESD KFFINGSNWEGILGLAYAEI ARPDDSLEPFFDSLVKQTHV PNLFSLQLCGAGFPLNQSEV LASVGGSMIIGGIDHSLYTG SLWYTPIRREWYYEVIIVRV EINGQDLKMDCKEYNYDKSI VDSGTTNLRLPKKVFEAAVK SIKAASSTEKFPDGFWLGEQ LVCWQAGTTPWNIFPVISLY LMGEVTNQSFRITILPQQYL RPVEDVATSQDDCYKFAISQ SSTGTVMGAVIMEGFYVVFD RARKRIGFAVSACHVHDEFR TAAVEGPFVTLDMEDCGYNI PQTDEST

Data sets:
Data typeCount
1H chemical shifts319
13C chemical shifts917
15N chemical shifts324

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
  • Hide all

Assembly:

Entity Assembly IDEntity NameEntity ID
1BACE1 monomer1

Entities:

Entity 1, BACE1 monomer 407 residues - Formula weight is not available

1   ASPGLUGLUPROGLUGLUPROGLYARGARG
2   GLYSERPHEVALGLUMETVALASPASNLEU
3   ARGGLYLYSSERGLYGLNGLYTYRTYRVAL
4   GLUMETTHRVALGLYSERPROPROGLNTHR
5   LEUASNILELEUVALASPTHRGLYSERSER
6   ASNPHEALAVALGLYALAALAPROHISPRO
7   PHELEUHISARGTYRTYRGLNARGGLNLEU
8   SERSERTHRTYRARGASPLEUARGLYSGLY
9   VALTYRVALPROTYRTHRGLNGLYLYSTRP
10   GLUGLYGLULEUGLYTHRASPLEUVALSER
11   ILEPROHISGLYPROASNVALTHRVALARG
12   ALAASNILEALAALAILETHRGLUSERASP
13   LYSPHEPHEILEASNGLYSERASNTRPGLU
14   GLYILELEUGLYLEUALATYRALAGLUILE
15   ALAARGPROASPASPSERLEUGLUPROPHE
16   PHEASPSERLEUVALLYSGLNTHRHISVAL
17   PROASNLEUPHESERLEUGLNLEUCYSGLY
18   ALAGLYPHEPROLEUASNGLNSERGLUVAL
19   LEUALASERVALGLYGLYSERMETILEILE
20   GLYGLYILEASPHISSERLEUTYRTHRGLY
21   SERLEUTRPTYRTHRPROILEARGARGGLU
22   TRPTYRTYRGLUVALILEILEVALARGVAL
23   GLUILEASNGLYGLNASPLEULYSMETASP
24   CYSLYSGLUTYRASNTYRASPLYSSERILE
25   VALASPSERGLYTHRTHRASNLEUARGLEU
26   PROLYSLYSVALPHEGLUALAALAVALLYS
27   SERILELYSALAALASERSERTHRGLULYS
28   PHEPROASPGLYPHETRPLEUGLYGLUGLN
29   LEUVALCYSTRPGLNALAGLYTHRTHRPRO
30   TRPASNILEPHEPROVALILESERLEUTYR
31   LEUMETGLYGLUVALTHRASNGLNSERPHE
32   ARGILETHRILELEUPROGLNGLNTYRLEU
33   ARGPROVALGLUASPVALALATHRSERGLN
34   ASPASPCYSTYRLYSPHEALAILESERGLN
35   SERSERTHRGLYTHRVALMETGLYALAVAL
36   ILEMETGLUGLYPHETYRVALVALPHEASP
37   ARGALAARGLYSARGILEGLYPHEALAVAL
38   SERALACYSHISVALHISASPGLUPHEARG
39   THRALAALAVALGLUGLYPROPHEVALTHR
40   LEUASPMETGLUASPCYSGLYTYRASNILE
41   PROGLNTHRASPGLUSERTHR

Samples:

sample_1: beta-site APP Cleaving Enzyme 1, [U-2H; U-15N; U-13C], 0.9 mM

condi-1: pH: 7.5 na; temperature: 298 K

Experiments:

NameSampleSample stateSample conditions
1H-15N TROSYnot availablenot availablenot available
3D-TROSY-HNCACBnot availablenot availablenot available
3D-TROSY-HNCACOnot availablenot availablenot available
3D-TROSY-HNCAnot availablenot availablenot available
3D-TROSY-HNCOnot availablenot availablenot available
3D-TROSY-HNCOCAnot availablenot availablenot available
3D-TROSY-CT-CACB(CO)NHnot availablenot availablenot available
4D TROSY-HNCOCAnot availablenot availablenot available
4D TROSY-HNCACOnot availablenot availablenot available

Software:

NMRpipe - data processing

NMR spectrometers:

  • Varian INOVA 600 MHz

Related Database Links:

PDB
DBJ BAA86463 BAB29317 BAB29370 BAC28156 BAC30889
GB AAF04142 AAF04143 AAF04144 AAF13715 AAF17079
REF NP_001039996 NP_001193977 NP_001247857 NP_001276783 NP_035922
SP P56817 P56818 P56819 Q2HJ40
TPG DAA22394
AlphaFold P56817 P56818 P56819 Q2HJ40

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated shifts
SPARKY: Backbone or all simulated shifts