BMRB Entry 6428
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR6428
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Title: Probing the pH-dependent structural features of a-KTx12.1, a potassium channel blocker from the scorpion Tityus serrulatus PubMed: 15772309
Deposition date: 2004-12-10 Original release date: 2006-08-11
Authors: Oyama, Sergio; Pristovsek, Primoz; Franzoni, Lorella; Pertinhez, Thelma; Schinina, Eugenia; Luecke, Christian; Rueterjans, Heinz; Arantes, Eliane; Spisni, Alberto
Citation: Oyama, Sergio; Pristovsek, Primoz; Franzoni, Lorella; Pertinhez, Thelma; Schinina, Eugenia; Luecke, Christian; Rueterjans, Heinz; Arantes, Eliane; Spisni, Alberto. "Probing the pH-dependent structural features of alpha-KTx12.1 a potassium channel blocker from the scorpion Tityus serrulatus" Protein Sci. 14, 1025-1038 (2005).
Assembly members:
alpha-KTx12.1, polymer, 40 residues, Formula weight is not available
Natural source: Common Name: Brazilian scorpion Taxonomy ID: 6887 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Tityus serrulatus
Experimental source: Production method: purified from the natural source
Entity Sequences (FASTA):
alpha-KTx12.1: WCSTCLDLACGASRECYDPC
FKAFGRAHGKCMNNKCRCYT
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | alpha-KTx12.1 | 1 |
Entities:
Entity 1, alpha-KTx12.1 40 residues - Formula weight is not available
| 1 | TRP | CYS | SER | THR | CYS | LEU | ASP | LEU | ALA | CYS | |
| 2 | GLY | ALA | SER | ARG | GLU | CYS | TYR | ASP | PRO | CYS | |
| 3 | PHE | LYS | ALA | PHE | GLY | ARG | ALA | HIS | GLY | LYS | |
| 4 | CYS | MET | ASN | ASN | LYS | CYS | ARG | CYS | TYR | THR |
Samples:
sample_1: alpha-KTx12.10.5 – 0.7 mM
condition_1: pH: 4.5; temperature: 308 K
condition_2: pH: 6.0; temperature: 308 K
condition_3: pH: 7.0; temperature: 308 K
Experiments:
| Name | Sample | Sample state | Sample conditions |
|---|---|---|---|
| NOESY | not available | not available | not available |
| TOCSY | not available | not available | not available |
| COSY | not available | not available | not available |
Software:
FELIX v97 -
NMR spectrometers:
- Varian Inova 600 MHz
- Bruker DMX 600 MHz