BMRB Entry 17185

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR17185

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Title:
Determination of the Binding Specificity of the Integral Membrane Protein by Saturation Transfer Difference NMR: RGD Peptide Ligands Binding to Integrin alphaIIbBeta3
Deposition date:
2010-09-10
Original release date:
2010-11-10
Authors:
Meinecke, Robert; Meyer, Bernd
Citation:

Citation: Meinecke, Robert; Meyer, Bernd. "Determination of the Binding Specificity of an Integral Membrane Protein by Saturation Transfer Difference NMR: RGD Peptide Ligands Binding to Integrin alphaIIbBeta3"  J. Med. Chem. 44, 3059-3065 (2001).
PubMed: 11543674

Assembly members:

Assembly members:
cyclo, polymer, 5 residues, Formula weight is not available
alphaIIb, polymer, 42 residues, Formula weight is not available
beta3, polymer, 43 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: not available   Taxonomy ID: not available   Superkingdom: not available   Kingdom: not available   Genus/species: not available not available

Experimental source:

Experimental source:   Production method: chemical synthesis

Entity Sequences (FASTA):

Entity Sequences (FASTA):
cyclo: RGDXV
alphaIIb: GALEERAIPIWWVLVGVLGG LLLLTILVLAMWKVGFFKRN RP
beta3: PESPKGPDILVVLLSVMGAI LLIGLAALLIWKLLITIHDR KEF

Data sets:
  • binding constants
Data typeCount
binding constants6

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
  • Hide all

Assembly:

Entity Assembly IDEntity NameEntity ID
1cyclo1
2alphaIIb2
3beta33

Entities:

Entity 1, cyclo 5 residues - Formula weight is not available

1   ARGGLYASPDPNVAL

Entity 2, alphaIIb 42 residues - Formula weight is not available

1   GLYALALEUGLUGLUARGALAILEPROILE
2   TRPTRPVALLEUVALGLYVALLEUGLYGLY
3   LEULEULEULEUTHRILELEUVALLEUALA
4   METTRPLYSVALGLYPHEPHELYSARGASN
5   ARGPRO

Entity 3, beta3 43 residues - Formula weight is not available

1   PROGLUSERPROLYSGLYPROASPILELEU
2   VALVALLEULEUSERVALMETGLYALAILE
3   LEULEUILEGLYLEUALAALALEULEUILE
4   TRPLYSLEULEUILETHRILEHISASPARG
5   LYSGLUPHE

Related Database Links:

BMRB 16496 16497 16496 16497
PDB 2K1A 2K9J 2KNC 2RMZ 2RN0
DBJ BAG37735 BAI46167 BAG62151 BAJ17755
EMBL CAA29987
GB AAA35926 AAA52597 AAA53150 AAA60114 AAA65936 AAA35927 AAA36121 AAA52589 AAA52600 AAA60122
PRF 1403305A
REF NP_000410 XP_001114526 XP_001150497 XP_002827479 XP_003282434 NP_000203 XP_002748172 XP_002834363 XP_003270746 XP_004041501
SP P08514 P53711 P05106
AlphaFold P08514 P53711 P05106