BMRB Entry 6875

Chem Shift validation: AVS_anomalous, AVS_full
BMRB Entry DOI: doi:10.13018/BMR6875

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Title:
Solution structure of a biologically active human FGF-1 monomer, complexed to a hexasaccharide heparin-analogue
Deposition date:
2005-10-25
Original release date:
2006-11-16
Authors:
Canales, Angeles; Lozano, Rosa; Nieto, Pedro; Martin-Lomas, Manuel; Gimenez-Gallego, Guillermo; Jimenez-Barbero, Jesus
Citation:

Citation: Canales, Angeles; Lozano, Rosa; Lopez-Mendez, B.; Angulo, J.; Ojeda, R.; Nieto, Pedro; Martin-Lomas, Manuel; Gimenez-Gallego, Guillermo; Jimenez-Barbero, Jesus. "Solution NMR structure of a human FGF-1 monomer, activated by a hexasaccharide heparin-analogue"  FEBS J. 273, 4716-4727 (2006).
PubMed: 16995857

Assembly members:

Assembly members:
FGF-1, polymer, 139 residues, 15755 Da.
HLHS, polymer, 7 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: pRAT4

Entity Sequences (FASTA):

Entity Sequences (FASTA):
FGF-1: NLPPGNYKKPKLLYCSNGGH FLRILPDGTVDGTRDRSDQH IQLQLSAESVGEVYIKSTET GQYLAMDTDGLLYGSQTPNE ECLFLERLEENHYNTYISKK HAEKNWFVGLKKNGSCKRGP RTHYGQKAILFLPLPVSSD
HLHS: XXXXXXX

Data sets:
Data typeCount
13C chemical shifts235
15N chemical shifts125
1H chemical shifts780

Additional metadata:

  • Assembly
  • Samples and Experiments
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Assembly:

Entity Assembly IDEntity NameEntity ID
1FGF-11
2HLHS2

Entities:

Entity 1, FGF-1 139 residues - 15755 Da.

1   ASNLEUPROPROGLYASNTYRLYSLYSPRO
2   LYSLEULEUTYRCYSSERASNGLYGLYHIS
3   PHELEUARGILELEUPROASPGLYTHRVAL
4   ASPGLYTHRARGASPARGSERASPGLNHIS
5   ILEGLNLEUGLNLEUSERALAGLUSERVAL
6   GLYGLUVALTYRILELYSSERTHRGLUTHR
7   GLYGLNTYRLEUALAMETASPTHRASPGLY
8   LEULEUTYRGLYSERGLNTHRPROASNGLU
9   GLUCYSLEUPHELEUGLUARGLEUGLUGLU
10   ASNHISTYRASNTHRTYRILESERLYSLYS
11   HISALAGLULYSASNTRPPHEVALGLYLEU
12   LYSLYSASNGLYSERCYSLYSARGGLYPRO
13   ARGTHRHISTYRGLYGLNLYSALAILELEU
14   PHELEUPROLEUPROVALSERSERASP

Entity 2, HLHS 7 residues - Formula weight is not available

1   IDSGNSIDRNGYIDSGNSIPA

Related Database Links:

BMRB 15783 15960 16493 16494 16502 17464 17674
PDB 1AXM 1DJS 1DZC 1DZD 1E0O 1EVT 1HKN 1JQZ 1JT3 1JT4 1JT5 1JT7 1JTC 1JY0 1K5U 1K5V 1M16 1P63 1PZZ 1Q03 1Q04 1RG8 1RML 1RY7 1YTO 1Z2V 1Z4S 2AFG 2AQZ 2AXM 2ERM 2HW9 2HWA 2HWM 2HZ9 2J3P 2K43 2K4A 2K8R 2KI4 2KI6 2NTD 2Q9X 2RQ9 2UUS 3B9U 3BA4 3BA5 3BA7 3BAD 3BAG 3BAH 3BAO 3BAQ 3BAU 3BAV 3BB2 3CQA 3CRG 3CRH 3CRI 3CU1 3FGM 3FJ8 3FJ9 3FJA 3FJB 3FJC 3FJD 3FJE 3FJF 3FJH 3FJI 3FJJ 3FJK 3HAL 3HOM 3JUT 3K1X 3OJ2 3OJM 3OJV 3UD7 3UD8 3UD9 3UDA 4J23
DBJ BAF82451 BAG35227 BAI46827
EMBL CAA36206 CAA42869 CAA46661 CAI29610 CCE35537
GB AAA52446 AAA52638 AAA79245 AAB29057 AAH32697
PRF 1605206A
REF NP_000791 NP_001127073 NP_001138364 NP_001138406 NP_001138407
SP P05230 P20002 P34004 Q5NVQ3
AlphaFold P05230 P20002 P34004 Q5NVQ3

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